Metal-bioconjugates in anticancer therapy and diagnosis

Metallic Structure

We are currently exploring multifunctional metal-bioconjugates based on carbohydrates, steroids, and/or oligonucleotides that can act as active targets to over-expressed receptors of cancer cells. Special efforts are directed towards molecules able to selectively recognize G-quadruplex DNA structures (G4)

We are especially interested in metal compounds of the late transition groups 8-11. Last years we have explored how metal compounds' stereochemistry and the presence of hydrogen bonding can improve some properties of metallodrugs

Part of our research is focused on the development of new biosensors based on single-layer graphene (SLG) for the selective detection of biologically active molecules