Design, Interaction and Synthesis of Bioactive Compounds
Our team belongs to the Chemistry Research Institute Andrés M. del Río (IQAR), based in the University of Alcalá (UAH), Spain.
We have access to all UAH general scientific infrastructures. In addition, the team shares a Brucker Avance II 400 NMR, two dry boxes (MBRAUN 150B-G, MBRAUN Unilab), and an MBRAUN solvent drying system.
Interactions between metal conjugates and nucleic acids are investigated on an automatic viscosimeter (AVS 470 model) and a VA-CT52 thermostatic-bath equipped with a cooling probe VA-CK300.
The experiments on denaturation of G-quadruplex nucleic acids by FRET are performed in the Molecular Biology unit through specifically designed protocols and an RT-PCR instrument. The antitumor properties of the synthesized compounds are analyzed at the Cell Culture Facility.